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Referenced Capacitively Coupled Conductivity Detector for Capillary Electrophoresis
Author(s) -
Stojkovic Marko,
Schlensky Boris,
Hauser Peter C.
Publication year - 2013
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201300413
Subject(s) - capillary electrophoresis , capillary action , conductivity , thermal conductivity detector , detector , analytical chemistry (journal) , chemistry , buffer (optical fiber) , electrophoresis , chromatography , materials science , physics , computer science , optics , gas chromatography , telecommunications , composite material
A dual capacitively coupled contactless conductivity detector for capillary electrophoresis was developed. The two channels are arranged in a bridge configuration so that one of them acts as a reference whose signal is subtracted. This effectively compensates for the baseline conductivity of the separation buffer so that the electronic zero setting is not necessary. Changes in the buffer composition are automatically accounted for, as are temperature drifts. The system is demonstrated for the detection of inorganic model cations in capillary electrophoresis. Besides the use with two separate capillaries, one of which solely serves as reference, it was also found possible to use a single capillary which is looped back through the reference cell.