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Electrochemical Determination of the Anticancer Herbal Drug Shikonin at a Nanostructured Poly(hydroxymethylated‐3,4‐ethylenedioxythiophene) Modified Electrode
Author(s) -
Wu Liping,
Lu Limin,
Zhang Long,
Xu Jingkun,
Zhang Kaixin,
Wen Yangping,
Duan Xuemin,
Yang Fan
Publication year - 2013
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201300247
Subject(s) - pedot:pss , poly(3,4 ethylenedioxythiophene) , electrode , materials science , electrochemistry , conductive polymer , detection limit , chemical engineering , nanotechnology , nuclear chemistry , polymer , chemistry , chromatography , composite material , layer (electronics) , engineering
A simple and sensitive method is described for the electrochemical determination of shikonin, a widely used anti‐tumoral agent, based on its electrochemical oxidation at a nanostructured poly(hydroxymethylated‐3,4‐ethylenedioxy‐thiophene) (PEDOT‐MeOH) electrode, which was fabricated by a facile electropolymerization method. Compared with bare and poly(3,4‐ethylenedioxythiophene) (PEDOT) electrodes, the PEDOT‐MeOH film exhibited a distinctly higher activity for the electrooxidation of shikonin. The PEDOT‐MeOH electrode showed a wide linear response for shikonin in the concentration range from 1.0 nM to 10.0 µM with detection limit of 0.3 nM. Furthermore, the PEDOT‐MeOH electrode displayed high stability, good reproducibility and high sensitivity for the detection of shikonin.