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Development of a Carbon Nanotube Modified Ionic Liquid Electrode for the Voltammetric Determination of Methyldopa Levels in Urine
Author(s) -
PérezMella B.,
ÁlvarezLueje A.
Publication year - 2013
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201300241
Subject(s) - methyldopa , ionic liquid , electrode , differential pulse voltammetry , chemistry , urine , chromatography , carbon nanotube , anode , urine sample , voltammetry , cyclic voltammetry , glassy carbon , pyridinium , analytical chemistry (journal) , electrochemistry , materials science , organic chemistry , nanotechnology , medicine , biochemistry , blood pressure , radiology , catalysis
A glassy carbon electrode was modified with carbon nanotubes and the ionic liquid N ‐butyl pyridinium trifluoromethyl methanesulfonate for the determination of methyldopa in urine samples. Methyldopa exhibited a well‐defined anodic signal over a broad pH range of 2–10 and the peak current increased approximately 100 fold over that of the unmodified electrode. Accordingly, a novel method for the determination of methyldopa was proposed using differential pulse voltammetry. The peak current was linear over a methyldopa concentration range from 21 to 2111 ng mL −1 with a LOD of 6.9 ng mL −1 and a LOQ of 7.4 ng mL −1 . The method was applied to determine the excretion profile of methyldopa in urine without sample pretreatment.