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Electrocatalytic Oxidation of Cysteine at a CoSalophen/ n ‐(butyl) 4 SiW 12 O 40 Carbon Paste Electrode
Author(s) -
Kakhki Somayeh,
Shams Esmaeil,
Barsan Madalina M.
Publication year - 2013
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201300235
Subject(s) - differential pulse voltammetry , electrode , reproducibility , chemistry , cyclic voltammetry , carbon fibers , detection limit , carbon paste electrode , cobalt , cysteine , materials science , analytical chemistry (journal) , electrochemistry , inorganic chemistry , chromatography , organic chemistry , composite material , composite number , enzyme
In the present study, a novel mixture consisting of N , N ′‐bis(salicylidene)‐1,2‐phenylenediamino cobalt (CoSalophen, CoSal) complex and ( n ‐butyl) 4 SiW 12 O 40 (SiW 12 ), have been used to chemically modify a carbon paste electrode (CPE) for sensitive determination of cysteine (CySH). The electrocatalytic effect of the newly developed modified CPE towards oxidation of CySH was evaluated by comparing cyclic and differential pulse voltammograms in the presence of cysteine at bare, CoSal, SiW 12 and CoSal/SiW 12 modified CPE. The differential pulse voltammetry method was applied as a sensitive method for quantitative detection of CySH trace amounts, the experimental conditions being optimized in order to evaluate the best analytical parameters of the sensor. Reproducibility and stability studies were also performed and the sensor was applied for the determination of CySH in a pharmaceutical sample and in human blood serum and urine samples.