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Simultaneous Square‐Wave Voltammetric Determination of Paracetamol, Caffeine and Orphenadrine in Pharmaceutical Formulations Using a Cathodically Pretreated Boron‐Doped Diamond Electrode
Author(s) -
Eisele Ana Paula Pires,
Clausen Débora Nóbile,
Tarley César Ricardo Teixeira,
Dall'Antonia Luiz Henrique,
Sartori Elen Romão
Publication year - 2013
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201300137
Subject(s) - electrode , square wave , diamond , voltammetry , caffeine , electroanalytical method , materials science , chromatography , boron , detection limit , pharmaceutical formulation , chemistry , nuclear chemistry , electrochemistry , medicine , metallurgy , potentiometric titration , organic chemistry , physics , quantum mechanics , voltage , endocrinology
An electroanalytical method for the simultaneous determination of paracetamol (PAR), caffeine (CAF), and orphenadrine (ORPH) using the square‐wave voltammetry (SWV) and a cathodically pretreated boron‐doped diamond electrode was developed. The method exhibits linear responses to PAR, CAF, and ORPH in the concentration ranges 5.4×10 −7 –6.1×10 −5 M, 7.8×10 −7 –3.5×10 −5 M, and 7.8×10 −7 –3.5×10 −5 M, respectively, with detection limits of 2.3×10 −7 M, 9.6×10 −8 M, and 8.4×10 −8 M, respectively. The proposed method was successfully applied in the simultaneous determination of these analytes in pharmaceutical formulations.