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Simultaneous Voltammetric Determination of Captopril and Hydrochlorothiazide on a Graphene/Ferrocene Composite Carbon Paste Electrode
Author(s) -
Gholivand Mohammad Bagher,
Khodadadian Mehdi
Publication year - 2013
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201200665
Subject(s) - differential pulse voltammetry , electrode , ferrocene , captopril , hydrochlorothiazide , graphene , electrochemistry , carbon paste electrode , materials science , composite number , chemistry , cyclic voltammetry , nanotechnology , composite material , medicine , blood pressure , radiology
In this work, a voltammetric method has been developed for the simultaneous determination of captopril (CPT) and hydrochlorothiazide (HCT) in pharmaceutical combinations and clinical samples using a graphene/ferrocene composite carbon paste (GR/Fc/CP) electrode. The electrochemical behaviors of CPT and HCT were individually and simultaneously investigated at the surface of the GR/Fc/CP electrode. In differential pulse voltammetric (DPV) mode and under optimized experimental conditions, CPT and HCT gave linear responses over the concentration ranges 1.0–430 µM and 0.5–390 µM ( r 2 >0.99), respectively. The prepared electrode could be used for simultaneous determination of CPT and HCT in some real samples.