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A Dopamine Electrochemical Sensor Based on Molecularly Imprinted Poly(acrylamidophenylboronic acid) Film
Author(s) -
Hong Shuangjin,
Lee Lawrence Yoon Suk,
So MingHim,
Wong KwokYin
Publication year - 2013
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201200631
Subject(s) - differential pulse voltammetry , cyclic voltammetry , ascorbic acid , polymerization , materials science , electrochemical gas sensor , electrochemistry , molecularly imprinted polymer , electrode , detection limit , voltammetry , chemistry , inorganic chemistry , chemical engineering , selectivity , polymer , organic chemistry , chromatography , catalysis , food science , composite material , engineering
Molecularly imprinted polymeric films were prepared on the surface of a gold electrode by reductive electrochemical co‐polymerization of 3‐acrylamidophenylboronic acid (AABA), acrylamide (as spacer monomer), and N,N′ ‐methylenebisacrylamide (as crosslinker monomer) in the presence of dopamine in water. The analytical determination of dopamine was investigated with this molecularly imprinted poly(AABA) film‐modified gold electrode using cyclic voltammetry, electrochemical quartz crystal balance, and differential pulse voltammetry. The covalent nature of dopamine‐boronic acid interaction as well as the negative charge on the molecularly imprinted polymeric film at physiological pH allowed excellent selectivity against ascorbic acid and other structurally similar interferents. The sensitivity of molecularly imprinted poly(AABA)‐modified electrode was further improved by depositing a thin layer of multiwalled carbon nanotubes on the gold electrode surface prior to electropolymerization. The increased surface area due to the presence of carbon nanotubes improved the dopamine sensor’s detection limit to ∼20 nM as determined by differential pulse voltammetry. A linear dependence of peak current in the differential pulse voltammograms was obtained over the dopamine concentration range from 50 nM to 2 µM.