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Graphite‐Polyurethane and Graphite‐Silicone Rubber Composite Electrodes for Electrochemical Characterization and Determination of Minoxidil
Author(s) -
Sousa Rogerio A.,
DosSantos Sidney X.,
Cavalheiro Eder T. G.,
Brett Christopher M. A.
Publication year - 2013
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201200606
Subject(s) - cyclic voltammetry , graphite , materials science , polyurethane , differential pulse voltammetry , supporting electrolyte , electrode , silicone rubber , dielectric spectroscopy , electrochemistry , electrolyte , analytical chemistry (journal) , chromatography , chemistry , composite material
Graphite‐polyurethane (GPUE) and graphite‐silicone rubber (GSRE) electrodes have been used for oxidative determination of the vasodilator minoxidil in pharmaceutical samples and in plasma and urine electrolyte solutions. The electrooxidation process at 0.840 V (GPUE) and 0.860 V (GSRE) vs. SCE was characterized over a wide pH range by cyclic voltammetry and electrochemical impedance spectroscopy. Quantification using cyclic, differential pulse, and square‐wave voltammetry, gave results agreeing with high pressure liquid chromatography, that has similar micromolar detection limits, but with a simpler analytical procedure. Advantages of these composite electrodes are non‐adsorption of analyte or oxidation products, a long useful life and robustness.