Label‐Free Analysis of Thrombin or Hg 2+  Ions by Nucleic Acid‐Functionalized Graphene Oxide Matrices Assembled on Field‐Effect Transistors | Zendy

Sharon Etery | Zendy; Liu Xiaoqing | Zendy; Freeman Ronit | Zendy; Yehezkeli Omer | Zendy; Willner Itamar | Zendy

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Label‐Free Analysis of Thrombin or Hg 2+ Ions by Nucleic Acid‐Functionalized Graphene Oxide Matrices Assembled on Field‐Effect Transistors

Author(s) -

Sharon Etery,

Liu Xiaoqing,

Freeman Ronit,

Yehezkeli Omer,

Willner Itamar

Publication year - 2013

Publication title -

electroanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 128

eISSN - 1521-4109

pISSN - 1040-0397

DOI - 10.1002/elan.201200581

Subject(s) - aptamer , graphene , nucleic acid , yield (engineering) , oxide , ion , desorption , thrombin , chemistry , materials science , nanotechnology , analytical chemistry (journal) , biochemistry , organic chemistry , adsorption , genetics , platelet , immunology , metallurgy , biology

Graphene oxide (GO) is deposited onto the Al 2 O 3 gates of field‐effect transistor devices to yield a functional matrix for the sensing of thrombin or Hg 2+ ions. The deposition of an aptamer subunit against thrombin or a tailored nucleic acid with appropriate T mismatches on the GO, yield active surfaces for the analysis of thrombin or Hg 2+ ions. The desorption of the aptamer‐subunit from GO, through the formation of the aptamer‐thrombin complex, or the desorption of the T–Hg 2+ –T‐bridged duplex DNA alter the gate potential, thus providing a signal for the sensing events.

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