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Preparation of Liposomal Progesterone and Its Application on the Measurement of Progesterone Interpreted via Electrochemical and Colorimetric Sensing Platforms
Author(s) -
Tien ChiaYing,
Jou Amily Fangju,
Fan NienChu,
Chuang MinChieh,
Ho Jaan Annie
Publication year - 2013
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201200563
Subject(s) - methylene blue , electrochemistry , biosensor , electrode , chemistry , combinatorial chemistry , nanotechnology , materials science , computer science , biochemistry , photocatalysis , catalysis
We herein demonstrate a successful synthesis of methylene blue (MB)‐encapsulated liposomal progesterone (LP) with an amplification merit beneficial for analytical applications. Both colormetric and electrochemical immunosensing strips for the leveling of progesterone, a hormone that helps to regulate the menstrual cycle of women, were achieved and characterized. Particular attention was given to the incorporation of an electrochemical screen‐printed electrode toward disposable and deployed diagnostics, enabling the reliable quantification of progesterone in connection to a LOD of 0.83 pg/mL. The novel, simple and specific amplification approach holds the promise to endorse a fast and high‐fidelity diagnostics required for immediate therapeutic attempts.