Enhanced Anodic Electrochemiluminescence from Co 2+ ‐Doped CdSe Nanocrystals for Alkaline Phosphatase Assay | Zendy

Wang Jing | Zendy; Zhang YanYan | Zendy; Zhao WeiWei | Zendy; Xu JingJuan | Zendy; Chen HongYuan | Zendy

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Enhanced Anodic Electrochemiluminescence from Co 2+ ‐Doped CdSe Nanocrystals for Alkaline Phosphatase Assay

Author(s) -

Wang Jing,

Zhang YanYan,

Zhao WeiWei,

Xu JingJuan,

Chen HongYuan

Publication year - 2013

Publication title -

electroanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 128

eISSN - 1521-4109

pISSN - 1040-0397

DOI - 10.1002/elan.201200558

Subject(s) - electrochemiluminescence , nanocrystal , doping , detection limit , inorganic chemistry , chemistry , aqueous solution , anode , materials science , analytical chemistry (journal) , electrode , nanotechnology , optoelectronics , chromatography

Co 2+ doped CdSe nanocrystals (CdSe:Co NCs) have been synthesized via a co‐precipitation method in homogeneous solutions. The anodic electrochemiluminescence (ECL) of CdSe:Co NCs with tripropylamine (TPrA) as co‐reactant was studied in aqueous solution for the first time. Co 2+ doped IIVI NCs systems exhibit strong coupling due to Co d‐orbital mixing with the valence band and conduction band of the IIVI host, which causes a ca. 3‐fold enhancement in ECL intensity compared with the undoped CdSe NCs. Benefiting from the strong anodic ECL emission of the doped NCs, we developed an alkaline phosphatase (ALP)‐responsive ECL system to detect the enzymatic processes successfully. An inhibition type anodic ECL strategy has been used to sensitively detect ALP ranging from 0.5 nM to 10 nM, with a detection limit of 0.1 nM.

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