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Carbon Nanotube Based Sensor for Simultaneous Determination of Acetaminophen and Ascorbic Acid Exploiting Multiple Response Optimization and Measures in the Presence of Surfactant
Author(s) -
Duarte Eduardo Henrique,
Kubota Lauro Tatsuo,
Tarley César Ricardo Teixeira
Publication year - 2012
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201200426
Subject(s) - ascorbic acid , differential pulse voltammetry , carbon nanotube , factorial experiment , calibration curve , chemistry , pulmonary surfactant , chromatography , bromide , detection limit , carbon paste electrode , standard addition , voltammetry , electrode , nuclear chemistry , cyclic voltammetry , materials science , analytical chemistry (journal) , organic chemistry , nanotechnology , electrochemistry , mathematics , biochemistry , statistics , food science
Abstract A simple procedure for the simultaneous determination of acetaminophen (AC) and ascorbic acid (AA) by differential pulse voltammetry (DPV) using a carbon nanotube paste electrode exploiting measures in cetylpyridinium bromide (CPB) medium is described. Under the best instrumental parameters of DPV, optimized by means of factorial design, the calibration plots in the range 100.0–700.0 µmol L −1 ( r =0.993) and 39.4–146.3 µmol L −1 ( r =0.995) with limits of detection of 7.1 and 2.1 µmol L −1 , were achieved for AA and AC, respectively. The developed method was successfully applied for the AC and AA determination in pharmaceutical formulations, whose accuracy was attested by comparison with HPLC method.