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Electrochemical Studies and Selective Detection of Thioridazine Using a Carbon Paste Electrode Modified with ZnS Nanoparticles and Simultaneous Determination of Thioridazine and Olanzapine
Author(s) -
Mashhadizadeh Mohammad Hossein,
Afshar Esmaeil
Publication year - 2012
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201200422
Subject(s) - differential pulse voltammetry , detection limit , carbon paste electrode , thioridazine , electrode , cyclic voltammetry , electrochemistry , materials science , voltammetry , chemistry , nanoparticle , chromatography , nanotechnology , medicine , chlorpromazine , endocrinology
A novel ZnS nanoparticle‐modified carbon paste electrode (ZnSNP‐MCPE) was fabricated and used to study the electrooxidation of thioridazine (TR) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The determination conditions, such as accumulation time, pH of solution, and modifier amount were optimized. The mechanism of the electrooxidation process on the surface of the modified electrode was studied electrochemically. A linear range of 0.1–36.0 µM with detection limit of 65.0 nM was obtained for TR. In a mixture containing TR and olanzapine (OLZ), the DPV peaks of two compounds can be well separate from each other with a potential difference of 425 mV. Finally, this method was successfully applied to determinate the TR content in real samples.