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Monodispersed Gold Nanoparticles Decorated Carbon Nanotubes as an Enhanced Sensing Platform for Nanomolar Detection of Tramadol
Author(s) -
Atta Nada F.,
Ahmed Rasha A.,
Amin Hatem M. A.,
Galal Ahmed
Publication year - 2012
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201200344
Subject(s) - detection limit , ascorbic acid , carbon nanotube , colloidal gold , materials science , nanoparticle , electrochemistry , electrode , carbon fibers , composite number , nuclear chemistry , electrochemical gas sensor , chemical engineering , nanotechnology , chemistry , chromatography , composite material , food science , engineering
A promising composite‐modified glassy carbon electrode is fabricated by electrodeposition of mono‐dispersed gold nanoparticles onto carbon nanotubes (AuNPs/CNTs/GCE). The electroanalysis of Tramadol (TRA) was achieved by different electrochemical techniques. The effect of different parameters including pH, concentration and potential scan on the oxidation current signal of TRA was investigated. Large excess of ascorbic acid (AA) and uric acid (UA) with a maximum molar ratio of 1/1000 and 1/100, respectively, did not interfere with the response of TRA. The detection limit with high sensitivity is 68 nM. TRA was successfully determined in pharmaceutical dosage forms, without any pretreatment of the samples.