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Simultaneous Determination of Caffeine and Acetylsalicylic Acid in Pharmaceutical Formulations Using a Boron‐Doped Diamond Film Electrode by Differential Pulse Voltammetry
Author(s) -
Faria Eric Oliveira,
Lopes Junior Antônio Carlos Viera,
Souto Dênio Emanuel Pires,
Leite Fernando Roberto Figueiredo,
Damos Flávio Santos,
de Cássia Silva Luz Rita,
dos Santos Alexandre Soares,
Franco Diego Leoni,
dos Santos Wallans Torres Pio
Publication year - 2012
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201200018
Subject(s) - differential pulse voltammetry , repeatability , detection limit , analytical chemistry (journal) , calibration curve , electrode , pharmaceutical formulation , boron , voltammetry , chemistry , caffeine , diamond , materials science , cyclic voltammetry , chromatography , electrochemistry , medicine , organic chemistry , endocrinology
This work presents a simple, fast and low‐cost method for simultaneous determination of acetylsalicylic acid (ASA), without alkaline hydrolysis and caffeine (CF) in pharmaceutical formulations using a boron‐doped diamond as the working electrode through differential pulse voltammetry. A good repeatability was reached for 20 measurements, with a low relative standard deviation of less than 1.0 %. The calibration curves presented a great linear correlation coefficient for both drugs ( R =0.999) with a limit of detection of 1.6×10 −7 mol L −1 for CF and 2.3×10 −7 mol L −1 for ASA. The system was validated in comparison with the official method.