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Voltammetric Determination of Clozapine in Pharmaceutical Formulations and Biological Fluids Using an In Situ Surfactant‐Modified Carbon Ionic Liquid Electrode
Author(s) -
Arvand M.,
Shiraz M. Ghasempour
Publication year - 2012
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100587
Subject(s) - pulmonary surfactant , electrode , ionic liquid , chemistry , in situ , chromatography , ionic bonding , carbon fibers , analytical chemistry (journal) , materials science , ion , organic chemistry , composite number , catalysis , biochemistry , composite material
A carbon ionic liquid electrode modified in situ with sodium dodecylsulfate (SDS) was developed for the determination of clozapine (CLZ). These studies revealed that the oxidation of CLZ is facilitated at an in situ surfactant‐modified carbon ionic liquid electrode (ISS‐CILE). After optimization of analytical conditions, the peak currents for CLZ were found to vary linearly with its concentrations in the range of 1×10 −9 –1×10 −7 mol L −1 with a slope of 2.18 µA/µmol L −1 . The LOD and LOQ of the electrode were 2.08×10 −10 mol L −1 and 6.95×10 −10 mol L −1 , respectively. The proposed method was employed for the determination of CLZ in pharmaceutical formulations, blood serum and plasma samples without any pretreatment steps.