Premium
Antineoplasic Drug Methotrexate Redox Mechanism Using a Glassy Carbon Electrode
Author(s) -
Pontinha A. D. R.,
Jorge S. M. A.,
Diculescu V. C.,
Vivan M.,
OliveiraBrett A. M.
Publication year - 2012
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100558
Subject(s) - redox , chemistry , electrochemistry , electron transfer , electrode , glassy carbon , inorganic chemistry , methotrexate , carbon fibers , photochemistry , materials science , cyclic voltammetry , immunology , biology , composite material , composite number
Abstract Methotrexate (MTX) is an antimetabolite of folic acid indicated in the treatment of a variety of cancers. The electrochemical behaviour of MTX on a glassy carbon electrode was investigated. The MTX oxidation is a complex, pH‐dependent, diffusion‐controlled irreversible process and proceeds with the transfer of two electrons and two protons and the formation of one electroactive product, 7‐hydroxymethotrexate that undergoes a reversible redox reaction. The MTX reduction is a pH‐dependent, quasi‐reversible process and involves the transfer of two electrons and two protons leading to the formation of an electroactive product.