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A Simple Strategy for Simultaneous Determination of Paracetamol and Caffeine Using Flow Injection Analysis with Multiple Pulse Amperometric Detection
Author(s) -
Silva Wesley C.,
Pereira Polyana F.,
Marra Mariana C.,
Gimenes Denise T.,
Cunha Rafael R.,
da Silva Rodrigo A. B.,
Munoz Rodrigo A. A.,
Richter Eduardo M.
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100512
Subject(s) - amperometry , analyte , flow injection analysis , chromatography , chemistry , detection limit , selectivity , pharmaceutical formulation , analytical chemistry (journal) , electrode , electrochemistry , organic chemistry , catalysis
In this work, we report a simple and novel strategy for simultaneous analysis using flow injection analysis with multiple pulse amperometric (FIA‐MPA) detection. The proposed strategy was successfully used for simultaneous determination of paracetamol and caffeine (model analytes) in pharmaceutical formulations. A sequence of potential pulses (waveform) was selected in such a way that PA is selectively oxidized at E 1 (+1.20 V/50 ms) and both compounds (PA+CA) are simultaneously oxidized at E 2 (+1.55 V/50 ms); hence, current subtraction (using a correction factor ) can be used for the selective determination of CA. The proposed FIA method is simple, cheap, fast (140 injections h −1 ), and present selectivity for the determination of both compounds in pharmaceutical samples, with results similar to those obtained by HPLC at a 95 % confidence level.