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Insight into Amyloid Formation Using Congo Red as the Electrochemical Probe
Author(s) -
Veloso Anthony J.,
Chan Tiffiny,
Wing Sze Hung Vinci,
Lam Leayen,
Kerman Kagan
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100329
Subject(s) - congo red , differential pulse voltammetry , electrochemistry , amyloid (mycology) , cyclic voltammetry , chemistry , combinatorial chemistry , electrode , inorganic chemistry , adsorption
The amyloid‐β (Aβ) aggregation pathway is an important target for the discovery of drugs that can prevent or delay the onset of Alzheimer’s disease (AD). The electrochemistry of Congo Red (CR) represents a particularly promising tool for screening of Aβ‐binding therapeutics in a rapid and cost‐effective format. The results of the differential pulse voltammetry (DPV) measurements were confirmed using simultaneous UV‐vis analysis of the same incubated Aβ samples. The early changes in the electrochemical signals were attributed to the interaction of the Aβ oligomers with CR. The electrochemical approach, in principle, allowed monitoring small molecule‐Aβ interactions on the time scale of aggregation.