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Nanoscale Manipulation of Prednisolone as Electroactive Configuration Using Molecularly Imprinted‐Multiwalled Carbon Nanotube Paste Electrode
Author(s) -
Rezaei Behzad,
MirahmadiZare S. Z.
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100261
Subject(s) - molecularly imprinted polymer , detection limit , materials science , electrode , electrochemical gas sensor , calibration curve , differential pulse voltammetry , carbon nanotube , electrochemistry , cyclic voltammetry , selectivity , chemical engineering , nanotechnology , chromatography , chemistry , catalysis , organic chemistry , engineering
Prednisolone has no suitable configuration for electroactivation in the potential window from −1.2 to +1.5 V. In this paper, a new catalytic application of molecularly imprinted polymers (MIP) was employed to achieve a suitable prednisolone conformation for electrochemical oxidation. Also, MIP as a recognition element improved the selectivity of the sensor for determination of prednisolone. In addition, to improve the sensitivity of the electrode multiwalled carbon nanotubes (MWCNT) were used in the preparation of MIP. Using differential pulse voltammetry (DPV) under optimized conditions, the calibration curve showed a linear dynamic range (0.08–160.00 µM) with a detection limit of 0.05 µM ( S / N =3). The modified electrode was successfully applied as prednisolone sensor in real samples such as plasma, urine and pharmaceutical formulation.