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Electrochemistry of Levo‐Thyroxin on Edge‐Plane Pyrolytic Graphite Electrode: Application to Sensitive Analytical Determinations
Author(s) -
Khafaji Mona,
Shahrokhian Saeed,
Ghalkhani Masoumeh
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100204
Subject(s) - pyrolytic carbon , detection limit , electrode , electrochemistry , graphite , electrolyte , glassy carbon , materials science , analytical chemistry (journal) , selectivity , supporting electrolyte , cyclic voltammetry , inorganic chemistry , chemistry , chromatography , composite material , pyrolysis , organic chemistry , catalysis
The electrochemical response of sodium levo‐thyroxin (T 4 ) at the surface of an edge plane pyrolytic graphite (EPPG) electrode is investigated using cyclic voltammetric technique in the presence of 0.1 M HCl as supporting electrolyte. T 4 underwent totally irreversible oxidation at this system and a well‐defined peak at 821 mV was obtained. Compared to the signals obtained in the optimized conditions at bare glassy carbon and carbon paste electrodes, the oxidation current of T 4 at an EPPG electrode was greatly enhanced. The electrochemical process of T 4 was explored and the experimental conditions were optimized. The oxidation peak current represented a linear dependence on T 4 concentration from 0.01 to 10 µM. The detection limit of 3 nM ( S / N =3) was obtained for 250 s accumulation at 0.3 V. Determination of T 4 in a synthetic serum sample demonstrated that this sensor has good selectivity and high sensitivity.