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Electroanalytical Performance of (SiPy + Cl − /CuTsPc) 5 LbL Film for Detecting Promethazine Hydrochloride
Author(s) -
de Jesus Cliciane Guadalupe,
Sampaio Forte Cristiane Maria,
Wohnrath Karen,
Andrade Pessôa Christiana,
de Sá Soares Janete Elisa,
Fujiwara Sérgio Toshio,
de LimaNeto Pedro,
Nunes Correia Adriana
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100202
Subject(s) - detection limit , chromatography , promethazine , hydrochloride , analytical chemistry (journal) , chemistry , materials science , organic chemistry , medicine , anesthesia
A (SiPy + Cl − /CuTsPc) 5 layer‐by‐layer film was employed for the electroanalytical determination of promethazine hydrochloride in BR buffer pH 5.0 with peaks at 0.48 and 0.79 V. After optimisation of the square‐wave parameters ( f =100 s −1 , a =40 mV and Δ E s =2 mV), the peak at 0.79 V was used for quantification and a detection limit of 8.71×10 −9 mol L −1 and a quantification limit of 9.31×10 −8 were calculated. The applicability of this procedure was tested on commercial formulations of promethazine hydrochloride by observing the stability, specificity, recovery and precision of the procedure in complex samples, without any preliminary treatment.