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A Glucose Sensor Based on an Aminophenyl Boronic Acid Bonded Conducting Polymer
Author(s) -
Das Debasmita,
Kim DongMin,
Park DeogSu,
Shim YoonBo
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100145
Subject(s) - boronic acid , chemistry , covalent bond , detection limit , polymer , polymer chemistry , organic chemistry , combinatorial chemistry , chromatography
3‐Aminophenyl boronic acid (APBA) bonded on the conducting polymer layer was prepared and used for detection of saccharides through the complexation between boronic acid and diol groups of saccharide. The probe was prepared by electropolymerization of 5,2′ : 5,2′′‐terthiophene‐3′‐carboxylic acid (TTCA), followed by covalent bond formation with APBA. It provides the site for the formation of tetrahedral boronate ester on the polymer layer (pTTCA). Each surface was characterized by CV, XPS, and QCM. Results show a dynamic range between 0.9 and 9.1 µM and a detection limit of 0.49 µM for glucose. The sensor was also applied for the detection of other saccharides including galactose and mannose. The performance of the sensor was evaluated in a human saliva sample.