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Potentiometric Sensing of Lamotrigine Based on Molecularly Imprinted Polymers
Author(s) -
Sadeghi Hayedeh Bagheri,
Ebrahimi Soltan Ahmad,
Tamaddon Atefeh,
Bozorgvar Fatemeh,
Afifinia Hadi,
Almasian Nasim,
Mollaei Somayeh
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100140
Subject(s) - potentiometric titration , molecularly imprinted polymer , detection limit , electrode , potentiometric sensor , lamotrigine , selectivity , polymer , chemistry , electroanalytical method , ion selective electrode , analytical chemistry (journal) , chromatography , organic chemistry , neuroscience , epilepsy , biology , catalysis
In the present work a novel potentiometric sensor, based on a noncovalent imprinted polymer, was developed for determination of Lamotrigine (LTG). At optimized conditions the electrode exhibited a Nernstian response (30.8±1.0 mV decade −1 ) in a concentration range of 1×10 −6 to 1×10 −3 M with a detection limit of 8×10 −7 mol L −1 . The potential response of the electrode was constant in the pH range of 1.0–5.0. The electrode demonstrated a response time of ∼30 s. The selectivity coefficient of the sensor toward a number of different drugs with molecular similarities and some metal ions was evaluated. The electrode was examined for determination of LTG in real samples.