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Flow‐Injection Amperometric Method for Determination of Diclofenac in Pharmaceutical Formulations Using a Boron‐Doped Diamond Electrode
Author(s) -
Gimenes D. T.,
de Freitas J. M.,
Munoz R. A. A.,
Richter E. M.
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100126
Subject(s) - amperometry , detection limit , electrode , electrolyte , diamond , supporting electrolyte , analytical chemistry (journal) , correlation coefficient , flow injection analysis , boron , chemistry , chromatography , materials science , electrochemistry , statistics , mathematics , organic chemistry
Abstract This paper describes the determination of diclofenac (DCF) in pharmaceutical formulations using flow injection method with multiple pulse amperometric detection. Unmodified boron‐doped diamond (BDD) is used as working electrode and 0.10 mol L −1 sulfuric acid as supporting electrolyte. The system exhibited sharp current response peaks and excellent stability of the analytical signal ( RSD =1.0 %, n =10). The linear response range from 5 to 50 µmol L −1 was obtained by using an injected volume of 50 µL, with good correlation coefficient ( R =0.998). The limits of detection ( LOD ) and quantification ( LOQ ) were found to be 0.14 and 0.46 µmol L −1 , respectively. The sampling frequency was calculated about 135 injections h −1 .