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Electrochemical Determination of Norepinephrine on Cathodically Pretreated Poly(1,5‐diaminonaphthalene) Modified Electrode
Author(s) -
Guedes da Silva Quésia,
Vieira Barbosa Nathália,
de Pieri Troiani Estela,
Censi Faria Ronaldo
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201100001
Subject(s) - ascorbic acid , detection limit , electrochemistry , cyclic voltammetry , electrode , differential pulse voltammetry , materials science , platinum , cathodic protection , chemistry , chromatography , organic chemistry , food science , catalysis
A sensitive and simple electrochemical method for norepinephrine (NE) determination was developed based on a poly(1,5‐diaminonaphthalene) film electrode (PDAN). Cathodically pretreated PDAN presents good selectivity, sensitivity, and reproducibility for NE. The polymer film can be easily electropolymerized onto a platinum electrode by cyclic voltammetry in 1.0 M HClO 4 . A cathodic pretreatment, consisting of the application of a potential of −0.7 V for 3 s (vs. Ag/AgCl) to PDAN before each voltammetric measurement, enhanced the electrochemical activity of NE with no inference of ascorbic acid (AA). In optimized conditions, PDAN presents linear responses for NE in the range of 9.90 to 90.9 µM by differential pulse voltammetry (DPV) with a detection limit of 1.82 µM. A relative standard deviation of 3.0 % was obtained for 10 consecutive measurements of 40.0 µM NE solutions. The cathodically pretreated PDAN was successfully applied for NE determination in pharmaceutical formulation samples.