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A Nonenzymatic Amperometric Method for Fructosyl‐Valine Sensing Using Ferroceneboronic Acid
Author(s) -
Chien HuiChing,
Chou TseChuan
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201000426
Subject(s) - amperometry , ferrocene , chemistry , boronic acid , valine , redox , electrochemistry , glassy carbon , hemoglobin , inorganic chemistry , electrode , combinatorial chemistry , chromatography , biochemistry , cyclic voltammetry , amino acid
Fructosyl valine (Fru‐Val) is a glycosylated component of hemoglobin (HbA 1c ) that can serve as a diagnostic target for type 2 diabetes. While average blood glucose levels fluctuate significantly, the more stable levels of HbA 1c can serve as a better long‐term diagnostic marker. Here a diagnostic system, incorporating an amperometric method, for detecting Fru‐Val (at +0.1 V vs. Ag/AgCl), using ferrocene boronic acid (FcBA) is presented. FcBA can complex diols, and has easily detectable redox properties. The boronic acid group in FcBA mediates complexation, while the Fe(II)/Fe(III) couple serves as a transducer. The diagnostic system, based on a miniaturized bare glassy carbon paste electrode (GCPE), has a fast response time.
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