Premium
Electrochemical Study of Gliclazide and Its Complexation with β ‐Cyclodextrin
Author(s) -
Radi AbdElgawad,
Eissa Shimaa
Publication year - 2010
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201000416
Subject(s) - gliclazide , differential pulse voltammetry , chemistry , cyclic voltammetry , electrochemistry , solubility , electroanalytical method , stability constants of complexes , cyclodextrin , voltammetry , diffusion , analytical chemistry (journal) , inorganic chemistry , electrode , chromatography , aqueous solution , potentiometric titration , organic chemistry , physics , thermodynamics , endocrinology , medicine , insulin
The electrochemical oxidation of gliclazide has been investigated at glassy carbon electrode in phosphate buffer solutions over the pH range 2.7–11.8 using cyclic and differential pulse voltammetry (DPV). Gliclazide exhibited one anodic peak in the pH range of 2.7–6.3 and a second peak was produced above pH 6.3. The oxidation processes have been shown to be irreversible and diffusion controlled. The formation of an inclusion complex of gliclazide with β ‐cyclodextrin ( β ‐CD) has been investigated by cyclic and differential pulse voltammetry. A phase solubility study with spectrophotometric detection has been also applied. The stability constant of the complex was determined to be 839 and 360 M −1 using the differential pulse voltammetric method and the phase solubility method, respectively.