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Voltammetric Determination of Chlorpheniramine Maleate Based on the Enhancement Effect of Sodium‐dodecyl Sulfate at Carbon Paste Electrode
Author(s) -
Lamani Shekappa D.,
Hegde Rajesh N.,
Savanur Anita P.,
Nandibewoor Sharanappa T.
Publication year - 2011
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201000369
Subject(s) - chlorpheniramine maleate , differential pulse voltammetry , chemistry , sodium dodecyl sulfate , detection limit , carbon paste electrode , voltammetry , cyclic voltammetry , electrode , sodium , chromatography , nuclear chemistry , inorganic chemistry , electrochemistry , organic chemistry
Abstract The voltammetric oxidation and determination of chlorpheniramine maleate (CPM) was studied at a carbon paste electrode (CPE) in the presence of sodium‐dodecyl sulfate (SDS) by cyclic and differential pulse voltammetry. The results indicated that the voltammetric response of chlorpheniramine maleate was markedly increased in the low concentration of SDS, suggesting that SDS exhibits observable enhancement effect to the determination of chlorpheniramine maleate. Under the optimal conditions the peak current was proportional to chlorpheniramine maleate concentration in the range of 8.0×10 −6 to 1.0×10 −4 M with detection limit of 1.7×10 −6 M by differential pulse voltammetry. The proposed method was successfully applied to the determination of chlorpheniramine in pharmaceutical and urine samples.