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Electrochemical Redox Behaviour of Temozolomide Using a Glassy Carbon Electrode
Author(s) -
Ghalkhani Masoumeh,
Fernandes Isabel P. G.,
Oliveira S. Carlos B.,
Shahrokhian Saeed,
OliveiraBrett Ana Maria
Publication year - 2010
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201000272
Subject(s) - temozolomide , electrochemistry , redox , chemistry , glassy carbon , electrode , electron transfer , proton , charge transfer coefficient , ion , inorganic chemistry , cyclic voltammetry , photochemistry , organic chemistry , medicine , surgery , chemotherapy , physics , quantum mechanics
The electrochemical behaviour of temozolomide on a glassy carbon electrode has been investigated. The reduction of temozolomide is an irreversible process, pH dependent, and the mechanism involves the addition of one electron and one proton to C5 to form an anion radical, causing the irreversible breakdown of the tetrazinone ring. The oxidation mechanism of temozolomide is an irreversible, adsorption‐controlled process, pH dependent up to value close to the p K a and occurs in two consecutive charge transfer reactions, with the formation of the hydroxylated product. The electroanalytical determination of TMZ led to a detection limit of 1.1 µM.