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Use of a Carbon‐Ink Microelectrode Array for Signal Enhancement in Microchip Electrophoresis with Electrochemical Detection
Author(s) -
Mecker Laura C.,
Filla Laura A.,
Martin R. Scott
Publication year - 2010
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201000118
Subject(s) - microelectrode , amperometry , multielectrode array , electrode , inkwell , materials science , resolution (logic) , signal (programming language) , capillary electrophoresis , carbon fibers , working electrode , nanotechnology , chromatography , electrochemistry , chemistry , computer science , programming language , composite material , artificial intelligence , composite number
In this communication, we demonstrate that a carbon ink microelectrode array, where the electrodes are held at the same potential, affords significant signal enhancement in microchip electrophoresis with amperometric detection. The ability to fabricate an array of carbon ink microelectrodes with a palladium decoupler was demonstrated and the resulting electrodes were integrated with a valving microchip design. The use of an 8 electrode array led to a significant improvement in the limits of detection at the expense of separation resolution due to the increased detection zone size. It is also shown that microdialysis sampling can be integrated with the microchip device and a multianalyte separation achieved.