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Voltammetric Behavior of Telmisartan and Cathodic Adsorptive Stripping Voltammetric Method for Its Assay in Pharmaceutical Dosage Forms and Biological Fluids
Author(s) -
Taşdemir İbrahim Hüdai,
Akay Mehmet Abdulkadir,
Erk Nevin,
Kılıç Esma
Publication year - 2010
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201000100
Subject(s) - telmisartan , detection limit , electrochemistry , voltammetry , chemistry , adsorption , adsorptive stripping voltammetry , cyclic voltammetry , square wave , chromatography , cathodic stripping voltammetry , stripping (fiber) , peak current , buffer solution , nuclear chemistry , analytical chemistry (journal) , materials science , electrode , organic chemistry , medicine , physics , voltage , quantum mechanics , composite material , blood pressure , radiology
Electrochemical behavior of Telmisartan and optimum conditions for its assay were investigated by using cyclic voltammetry and square‐wave voltammetry. All studies were based on the quasi‐reversible and adsorption‐controlled electrochemical reduction signal of TS at about −1.50 V versus Ag/AgCl at pH 10.0 in Britton‐Robinson buffer. The peak current was found to change linearly with concentration from 1.69 nM (0.87 µg/L) to 27.5 nM (14.15 µg/L). The limit of detection and the limit of quantification were found to be 1.05 nM (0.54 µg/L) and 3.49 nM (1.79 µg/L), respectively. The method was successfully applied to different samples with good recoveries at about 100 %.