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Electroanalytical Studies and Simultaneous Determination of Amlodipine Besylate and Atorvastatine Calcium in Binary Mixtures Using First Derivative of the Ratio‐Voltammetric Methods
Author(s) -
DoganTopal Burcu,
Bozal Burcin,
Demircigil B. Tolga,
Uslu Bengi,
Ozkan Sibel A.
Publication year - 2009
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200904689
Subject(s) - amlodipine , atorvastatin , derivative (finance) , chemistry , voltammetry , analytical chemistry (journal) , detection limit , electrochemistry , electrode , chromatography , materials science , pharmacology , medicine , blood pressure , financial economics , economics , radiology
The electrochemical behavior of atorvastatin and amlodipine at a glassy carbon electrode has been studied using different voltammetric techniques. First derivative of the ratio voltammetric methods for determination of amlodipine and atorvastatin in tablets in the presence of the other compound has been described. This technique depends on the measuring of first derivative of the ratio voltammograms of each concentration as a function of the increased concentrations. DP and SW voltammetric methods depend on first derivative of the ratio‐voltammetry by measurements of the selected potentials for amlodipine and atorvastatin. The linear response was within the range of 4×10 −6 –1×10 −4 M for amlodipine and 2×10 −6 –1×10 −4 M for atorvastatin. The proposed methods have been extensively validated.