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Metallophthalocyanine Based Carbon Paste Electrodes for the Determination of 2′,3′‐Dideoxyinosine
Author(s) -
Ozoemena Kenneth I.,
Stefanvan Staden RalucaIoana,
Nyokong Tebello
Publication year - 2009
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200904581
Subject(s) - detection limit , didanosine , phosphate buffered saline , electrochemistry , carbon paste electrode , carbon fibers , electrode , raw material , materials science , nuclear chemistry , chemistry , chromatography , human immunodeficiency virus (hiv) , organic chemistry , cyclic voltammetry , zidovudine , medicine , composite material , family medicine , viral disease , composite number
Novel electrochemical sensors based on carbon paste impregnated with metallopthalocyanine (MPc, M=Co, Fe) complexes, have been constructed for the assay of anti‐HIV drug 2′,3′‐dideoxyinosine (didanosine, DDI). Both modified electrodes showed electrocatalytic activity towards the oxidation of dideoxyinosine in phosphate buffer pH 7.4 with a working concentration range of 10 −6 –10 −4 mol/L and a detection limit of 10 −7 mol/L magnitude order. The sensor proved to be highly reliable for the assay of the purity of DDI ‐ raw material as well as for the uniformity content test of Videx tablets.