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Simultaneous Differential Pulse Voltammetric Determination of Ascorbic Acid and Caffeine in Pharmaceutical Formulations Using a Boron‐Doped Diamond Electrode
Author(s) -
Lourenção Bruna Cláudia,
Medeiros Roberta Antigo,
RochaFilho Romeu C.,
FatibelloFilho Orlando
Publication year - 2010
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200900612
Subject(s) - ascorbic acid , differential pulse voltammetry , calibration curve , chemistry , electrode , caffeine , boron , diamond , detection limit , voltammetry , analytical chemistry (journal) , standard addition , electrochemistry , chromatography , materials science , nuclear chemistry , cyclic voltammetry , medicine , organic chemistry , food science , endocrinology
A cathodically pretreated boron‐doped diamond electrode was used for the simultaneous anodic determination of ascorbic acid (AA) and caffeine (CAF) by differential pulse voltammetry. Linear calibration curves ( r =0.999) were obtained from 1.9×10 −5 to 2.1×10 −4 mol L −1 for AA and from 9.7×10 −6 to 1.1×10 −4 mol L −1 for CAF, with detection limits of 19 μmol L −1 and 7.0 μmol L −1 , respectively. This method was successfully applied for the determination of AA and CAF in pharmaceutical formulations, with results equal to those obtained using a HPLC reference method.