Premium
Development of a Controlled Release System for Risperidone Using Polypyrrole: Mechanistic Studies
Author(s) -
Svirskis Darren,
Wright Bryon E.,
TravasSejdic Jadranka,
Rodgers Anthony,
Garg Sanjay
Publication year - 2010
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200900401
Subject(s) - polypyrrole , biocompatibility , drug delivery , materials science , risperidone , nanotechnology , drug , biomedical engineering , chemical engineering , pharmacology , polymer , composite material , computer science , medicine , polymerization , schizophrenia (object oriented programming) , metallurgy , programming language , engineering
Polypyrrole (PPY) film has been selected as a platform material for drug delivery due to its inherent conductivity, ease of preparation and apparent biocompatibility. PPY films were prepared containing the antipsychotic drug risperidone as a model compound. Drug release profiles could be altered by applying different electrical stimulation to these films. Atomic force microscopy was used to investigate changes in PPY film thickness when different stimuli were applied. The highest levels of drug release were observed when PPY was reduced; this was accompanied by expansion of the film. Technology such as this could be utilized for implantable drug delivery devices, where the dose could be adjusted by external signaling.