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Electrochemical Oxidation of Sanguinarine and of Its Oxidation Products at a Glassy Carbon Electrode – Relevance to Intracellular Effects
Author(s) -
Diculescu Victor Constantin,
Enache Teodor Adrian,
Oliveira Paulo Jorge,
OliveiraBrett Ana Maria
Publication year - 2010
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200900367
Subject(s) - sanguinarine , cyclic voltammetry , glassy carbon , electrochemistry , chemistry , differential pulse voltammetry , redox , electrode , inorganic chemistry , organic chemistry , alkaloid
The electrochemical behavior of sanguinarine, a quaternary benzophenanthridine glycoside alkaloid with antimicrobial, anti‐inflammatory, antioxidant and/or immune‐stimulatory activities, was studied at a glassy carbon electrode using cyclic, differential pulse, and square wave voltammetry. The oxidation of sanguinarine is a quasireversible, diffusion‐controlled process and occurred in a cascade mechanism with the formation of several oxidation products which adsorbed at the electrode surface. The oxidation of sanguinarine is pH dependent and involves the transfer of the same number of electrons and protons. The adsorbed sanguinarine oxidation products are reversibly oxidized at the glassy carbon electrode surface and their oxidation for a wide range of pHs was also studied by differential pulse and square wave voltammetry. A mechanism for the oxidation of sanguinarine at glassy carbon electrode is proposed.