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Selective Electrochemical Determination of Paracetamol Using Nanostructured Film of Functionalized Thiadiazole Modified Electrode
Author(s) -
Kalimuthu Palraj,
Abraham John S.
Publication year - 2010
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200900362
Subject(s) - ascorbic acid , electrode , electrochemistry , detection limit , glassy carbon , phosphate buffered saline , chemically modified electrode , chemistry , working electrode , buffer solution , buffer (optical fiber) , inorganic chemistry , nuclear chemistry , materials science , cyclic voltammetry , chromatography , telecommunications , food science , computer science
This paper describes the selective electrochemical determination of paracetamol (PA) in the presence of important interferent, ascorbic acid (AA) using an ultrathin electropolymerized film of 5‐amino‐1,3,4‐thiadiazole‐2‐thiol (p‐ATT) modified glassy carbon (GC) electrode in 0.20 M phosphate buffer solution (pH 7.20). Bare GC electrode failed to resolve the voltammetric signals of AA and PA in a mixture. On the other hand, the p‐ATT modified electrode not only separated the voltammetric signals of AA and PA but also enhanced their peak currents. We achieved the lowest detection limit of 0.34 nM ( S / N =3) for PA at p‐ATT modified electrode.