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Electrochemical Aptasensors
Author(s) -
Sassolas Audrey,
Blum Loïc J.,
LecaBouvier Béatrice D.
Publication year - 2009
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200804554
Subject(s) - aptamer , signal (programming language) , chemistry , biosensor , amperometry , nanotechnology , potentiometric titration , electrochemistry , materials science , electrode , computer science , biology , microbiology and biotechnology , programming language
This review presents electrochemical aptasensors reported in the literature. Their development has been growing as evidenced by the increasing number of scientific publications on this subject since 2004. Aptasensors are presented according to their transduction mode, including the most described amperometric and impedimetric devices as well as FETs and the first very recently reported potentiometric aptasensor. ‘Signal‐on’ (positive readout signal) and less sensitive ‘signal‐off’ (negative readout signal) aptasensors are reviewed based on target binding‐induced conformational change of aptamers or on target binding‐induced strand displacement or even on both processes. Aptamer‐labeled and aptamer label‐free devices are presented separately.