Premium
Bioactive Hydrogel Layers on Microdisk Electrode Arrays: Cyclic Voltammetry Experiments and Simulations
Author(s) -
Justin Gusphyl,
Rahman Abdur Rub Abdur,
GuiseppiElie Anthony
Publication year - 2009
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200804548
Subject(s) - cyclic voltammetry , electrode , ferrocene , membrane , current density , analytical chemistry (journal) , materials science , biosensor , voltammetry , chemistry , electrochemistry , nanotechnology , chromatography , physics , biochemistry , quantum mechanics
Poly(hydroxyethylmethacrylate)‐based hydrogel membranes were applied to microfabricated, microdisk electrode arrays (MDEAs) of 50 μm (5184 disks), 100 μm (1296 disks) and 250 μm (207 disks) ( d / r =4; A= 0.1 cm 2 ) and studied by cyclic voltammetry (CV) in 1.0 mM ferrocene monocarboxylic acid (FcCO 2 H). The membrane produced an order of magnitude decrease in current densities and a shift to quasi reversibility due to a decrease in the D appt of FcCO 2 H, from 4.51×10 −6 cm 2 s −1 to 1.42×10 −8 cm 2 s −1 , (2.18×10 −8 cm 2 s −1 from release experiments). The MDEA050 (comprising 50 μm disks) maintained its enhanced current density attributes confirming its value as an effective electrode for biosensors. Finite element modeling (FEM) simulations successfully replicated the voltammograms of the MDEAs.