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The Preliminary Studies of Electrochemical Behavior of Paracetamol and Its Metabolites on Glassy Carbon Electrode by Voltammetric Methods
Author(s) -
Baranowska Irena,
Koper Marta
Publication year - 2009
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200804536
Subject(s) - glassy carbon , electrochemistry , calibration curve , chemistry , cyclic voltammetry , voltammetry , electrode , chromatography , analytical chemistry (journal) , nuclear chemistry , detection limit
The new, rapid and sensitive method for the determination of paracetamol (PAR) and its glucuronide (PG) and sulfate (PS) metabolites is proposed. The electrochemical properties of the compounds were examined by cyclic voltammetry (CV) on glassy carbon electrode (GCE). All measurements were carried out in Britton–Robinson buffers (BR) with different pH values over the pH range 1.81–7.24. The preliminary research indicated that PAR could be determined simultaneously with one of its metabolites. The linearity of calibration curves was obtained for concentrations between 1.65×10 −5 and 1.65×10 −4 M for PAR, 1.53×10 −5 and 1.53×10 −4 M for PG and 2.17×10 −5 and 1.52×10 −4 M for PS.