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Electrochemical Oxidation of Berberine and of Its Oxidation Products at a Glassy Carbon Electrode
Author(s) -
Diculescu Victor C.,
Enache Teodor Adrian,
Oliveira Paulo J.,
OliveiraBrett Ana Maria
Publication year - 2009
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200804516
Subject(s) - berberine , cyclic voltammetry , glassy carbon , electrochemistry , chemistry , differential pulse voltammetry , isoquinoline , electrode , inorganic chemistry , voltammetry , organic chemistry
The electrochemical behavior of berberine, an isoquinoline plant alkaloid with a wide spectrum of physiological effects, was studied at a glassy carbon electrode using cyclic, differential pulse and square‐wave voltammetry. The oxidation of berberine is a quasireversible, diffusion‐controlled process and occurred in a cascade mechanism with the formation of several oxidation products. The diffusion coefficient of berberine was calculated from cyclic voltammetry studies to be D =1.69×10 −6 cm 2 s −1 . The oxidation process of berberine is also pH dependent and the number of electrons and protons transferred was determined using differential pulse voltammetry. The formation of several oxidation products that adsorbed at the glassy carbon electrode surface was observed and their electrochemical behavior characterized. A mechanism for the oxidation of berberine at a glassy carbon electrode was proposed.