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New Protocol for Determination of Rifampicine by Adsorptive Stripping Voltammetry
Author(s) -
Tyszczuk Katarzyna,
Korolczuk Mieczyslaw
Publication year - 2009
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200804447
Subject(s) - adsorptive stripping voltammetry , stripping (fiber) , detection limit , electrode , anodic stripping voltammetry , adsorption , chemistry , voltammetry , supporting electrolyte , analytical chemistry (journal) , electrolyte , chromatography , materials science , electrochemistry , organic chemistry , composite material
For determinations of organic compounds by adsorptive stripping voltammetry till now the same material of the electrode has been used for the accumulation and stripping steps. This paper describes a new protocol for extending the range of organic compounds, which can be determined by adsorptive stripping voltammetry. In the proposed procedure the accumulation step was performed on the electrode modified by a lead film, which assures adsorption of the studied species on the modified electrode and then the stripping step of the accumulated substance was performed on the support of the lead film electrode. As an example rifampicine was accumulated by adsorption at the lead film electrode while in the stripping step lead film and then the accumulated rifampicine were oxidized at a glassy carbon electrode. Using an acetate buffer as a supporting electrolyte a calibration graph for rifampicine in the range from 2.5×10 −10 to 1×10 −8 mol L −1 was obtained. The detection limit for rifampicine following 60 s accumulation time was equal to 9×10 −11 mol L −1 . The obtained detection limit was comparable or lower than reported previously for other stripping voltammetric procedures. The proposed procedure was applied to rifampicine determination in pharmaceutical preparation.