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Electrocatalytic and Analytical Response of Cobalt Phthalocyanine Modified Carbon Paste Electrodes Towards Antimalarial Endoperoxide Artemisinin
Author(s) -
Debnath Chhanda,
Saha Pijus,
Ortner Astrid
Publication year - 2009
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200804432
Subject(s) - artemisinin , differential pulse voltammetry , cobalt , chemistry , electrode , phthalocyanine , cyclic voltammetry , detection limit , artemisia annua , carbon paste electrode , inorganic chemistry , plasmodium falciparum , chromatography , electrochemistry , organic chemistry , medicine , malaria , immunology
A cobalt phthalocyanine modified carbon paste electrode was constructed for the analysis of artemisinin in Artemisia annua plant. Artemisinin, a sesquiterpene endoperoxide, is a novel, important antimalarial drug and is used in the therapy against Plasmodium falciparum. The developed cobalt phthalocyanine modified electrode exhibited a significant electrocatalytic activity in presence of artemisinin when using cyclic and differential pulse voltammetry. Under optimized conditions in phosphate buffer of pH 7 a well defined voltammetric peak appeared at about −500 mV vs. Ag/AgCl. The differential pulse voltammetric peak current of artemisinin was increased linearly with the concentration range of 2.1×10 −5 to 5.3×10 −4 M ( R =0.9997). The limit of detection ( LOD ) was found to be 6.5×10 −6 M. The modified electrode was successfully tested for detecting artemisinin in complex plant materials.