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Selective Electrochemical Epinephrine Sensor Using Self‐Assembled Monomolecular Film of 1,8,15,22‐Tetraaminophthalocyanatonickel(II) on Gold Electrode
Author(s) -
Sivanesan Arumugam,
John Swamidoss Abraham
Publication year - 2008
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200804331
Subject(s) - electrode , ascorbic acid , amperometry , chemistry , palladium hydrogen electrode , standard hydrogen electrode , reference electrode , electrochemistry , detection limit , analytical chemistry (journal) , inorganic chemistry , quinhydrone electrode , working electrode , reversible hydrogen electrode , chromatography , food science
This article describes the highly sensitive and selective determination of epinephrine (EP) using self‐assembled monomolecular film (SAMF) of 1,8,15,22‐tetraamino‐phthalocyanatonickel(II) (4α‐Ni II TAPc) on Au electrode. The 4α‐Ni II TAPc SAMF modified electrode was prepared by spontaneous adsorption of 4α‐Ni II TAPc from dimethylformamide solution. The modified electrode oxidizes EP at less over potential with enhanced current response in contrast to the bare Au electrode. The standard heterogeneous rate constant ( k °) for the oxidation of EP at 4α‐Ni II TAPc SAMF modified electrode was found to be 1.94×10 −2 cm s −1 which was much higher than that at the bare Au electrode. Further, it was found that 4α‐Ni II TAPc SAMF modified electrode separates the voltammetric signals of ascorbic acid (AA) and EP with a peak separation of 250 mV. Using amperometric method the lowest detection limit of 50 nM of EP was achieved at SAMF modified electrode. Simultaneous amperometric determination of AA and EP was also achieved at the SAMF modified electrode. Common physiological interferents such as uric acid, glucose, urea and NaCl do not interfere within the potential window of EP oxidation. The present 4α‐Ni II TAPc SAMF modified electrode was also successfully applied to determine the concentration of EP in commercially available injection.