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In Vivo Electrochemical Detection of Nitroglycerin‐Derived Nitric Oxide in Tumor‐Bearing Mice
Author(s) -
Griveau Sophie,
Seguin Johanne,
Scherman Daniel,
Chabot Guy G.,
Bedioui Fethi
Publication year - 2009
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200804300
Subject(s) - in vivo , nitroglycerin (drug) , nitric oxide , chemistry , electrode , bioavailability , pharmacology , biomedical engineering , medicine , anesthesia , organic chemistry , biology , microbiology and biotechnology
The ability of an inserted electrode to detect in vivo NO in tumor was achieved by using a chemically modified Pt/Ir electrode as NO‐sensor and nitroglycerin NTG as NO donor. Enzymatically induced release of NO from NTG was tracked in the tumor, upon intra peritoneal injection of NTG. This approach allowed in vivo monitoring of the bioavailability of NO and could be applied to the in vivo study of candidate anticancer drugs acting on the NO pathways.