Premium
A Biomimetic Potentiometric Sensor Using Molecularly Imprinted Polymer for the Cetirizine Assay in Tablets and Biological Fluids
Author(s) -
Javanbakht Mehran,
Eynollahi Fard Solmaz,
Abdouss Majid,
Mohammadi Ali,
Reza Ganjali Mohammad,
Norouzi Parviz,
Safaraliee Leila
Publication year - 2008
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200804284
Subject(s) - molecularly imprinted polymer , potentiometric sensor , potentiometric titration , ethylene glycol dimethacrylate , methacrylic acid , precipitation polymerization , detection limit , polymer , chromatography , chemistry , cetirizine , ethylene glycol , monomer , selectivity , electrode , organic chemistry , radical polymerization , medicine , pharmacology , catalysis
Despite the increasing number of applications of molecularly imprinted polymers (MIPs) in analytical chemistry, the construction of a biomimetic potentiometric sensor remains still challenging. In this work, a biomimetic potentiometric sensor, based on a non‐covalent imprinted polymer was fabricated for the recognition and determination of cetirizine. The MIP was synthesized by precipitation polymerization, using cetirizine dihydrochloride as a template molecule, methacrylic acid (MAA) as a functional monomer and ethylene glycol dimethacrylate (EGDMA) as a cross linking agent. The sensor showed high selectivity and a sensitive response to the template in aqueous system. The MIP‐modified electrode exhibited Nernstian response (28.0±0.9 mV/decade) in a wide concentration range of 1.0×10 −6 to 1.0×10 −2 M with a lower detection limit of 7.0×10 −7 M. The electrode has response time of ca. 20 s, high performance, high sensitivity, and good long term stability (more than 5 months). The method was satisfactory and used to the cetirizine assay in tablets and biological fluids.