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Electrocatalytic Determination of 6‐Tioguanine at a p ‐Aminophenol Modified Carbon Paste Electrode
Author(s) -
Mirmomtaz Elham,
Asghar Ensafi Ali,
KarimiMaleh Hassan
Publication year - 2008
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200804273
Subject(s) - detection limit , electrode , cyclic voltammetry , chemistry , carbon paste electrode , analytical chemistry (journal) , electron transfer , reaction rate constant , carbon fibers , electrochemistry , nuclear chemistry , voltammetry , square wave , redox , linear range , inorganic chemistry , materials science , kinetics , chromatography , composite material , physics , quantum mechanics , voltage , composite number
A p ‐aminophenol modified carbon paste electrode ( p ‐APMCPE) was constructed for determination of an anticancer drug 6‐thioguanine (6‐TG). The cyclic voltammogram showed that the electrocatalytic oxidation of 6‐TG at the surface of p ‐APMCPE occurs at a potential about 840 mV less positive than at an unmodified electrode. Square‐wave voltammetry results presented that the electrocatalytic oxidation peak currents of 6‐TG in pH 9.0 had two linear dynamic ranges in the range of 0.2 to 8.0 and 8.0 to 350.0 μM 6‐TG with a detection limit of 0.08 μM. The kinetic parameters such as electron transfer coefficient ( α ) and rate constant were determined for the chemical reaction between 6‐TG and p ‐aminophenol. Finally, this method was evaluated for the determination of 6‐TG in 6‐thioguanine tablets and urine samples.