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Chip Based Electroanalytical Systems for Cell Analysis
Author(s) -
Spegel Christer,
Heiskanen Arto,
Skjolding Lars Henrik Dæhli,
Emnéus Jenny
Publication year - 2008
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200704130
Subject(s) - amperometry , nanotechnology , microelectrode , lab on a chip , electrode , computer science , materials science , living cell , microfluidics , chemistry , electrochemistry , biology , biological system
This review with 239 references has as its aim to give the reader an introduction to the kinds of methods used for developing microchip based electrode systems as well as to cover the existing literature on electroanalytical systems where microchips play a crucial role for ‘nondestructive’ measurements of processes related to living cells, i.e., systems without lysing the cells. The focus is on chip based amperometric and impedimetric cell analysis systems where measurements utilizing solely carbon fiber microelectrodes (CFME) and other nonchip electrode formats, such as CFME for exocytosis studies and scanning electrochemical microscopy (SECM) studies of living cells have been omitted. Included is also a discussion about some future and emerging nano tools and considerations that might have an impact on the future of “nondestructive” chip based electroanalysis of living cells.