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Voltammetric Detection of Ofloxacin in Human Urine at a Congo Red Functionalized Water‐Soluble Carbon Nanotube Film Electrode
Author(s) -
Yang Chunhai,
Xu Yanxia,
Hu Chengguo,
Hu Shengshui
Publication year - 2008
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.200704027
Subject(s) - ofloxacin , carbon nanotube , detection limit , nafion , congo red , electrochemistry , electrode , materials science , nuclear chemistry , carbon fibers , composite number , chemistry , nanotechnology , chromatography , composite material , organic chemistry , adsorption , biochemistry , ciprofloxacin , antibiotics
A simple physical method was developed for the surface modification and the solubilization of MWNTs in water by Congo red. The resulting water‐soluble MWNTs (MWNTs‐CR) can form stable and uniform films on solid supports when dried, which was used to fabricate MWNTs‐CR modified glassy carbon electrodes (MWNTs‐CR/GCE). Voltammetric studies showed that MWNTs‐CR/GCE exhibited a strong enhancement effect on the electrooxidation of ofloxacin. MWNTs‐CR films were also proved to possess overwhelming advantages as electrochemical sensing films over other commonly used MWNTs composite films (e.g., MWNTs‐DHP and MWNTs‐Nafion), reflected by the higher oxidation current, lower background and stronger accumulation capacity towards less soluble species. The sensitive oxidation of ofloxacin at MWNTs‐CR/GCE was used for the determination of ofloxacin. Under optimal conditions, the oxidation current was proportional to ofloxacin concentration in the ranges of 5×10 −8 –3.0×10 −5 M. The detection limit of 9×10 −9 M was obtained for 350 s accumulation at open circuit ( S / N =3). This method was applied to the determination of ofloxacin in human urine and the result was satisfying.